Video Gilbert's syndrome

Gilbert's syndrome (/ʒiːlˈbɛər/ zheel-BAIR), often shortened to GS, also called Gilbert–Meulengracht syndrome, is a genetic liver disorder and the most common hereditary cause of increased bilirubin and is found in up to 5% of the population (though some gastroenterologists maintain that it is closer to 10% in Caucasian people). A major characteristic is jaundice, caused by elevated levels of unconjugated bilirubin in the bloodstream (hyperbilirubinemia).
The cause of this hyperbilirubinemia is the reduced activity of the enzyme glucuronyltransferase, which conjugates bilirubin and a few other lipophilic molecules. Conjugation renders the bilirubin water-soluble, after which it is excreted in bile into the duodenum.

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